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PRESS RELEASES
November 23, 2021

The EU invests in a promising new COVID-19 therapy
         
The COVend research project aims to deliver a new therapy against COVID-19 that prevents the severe stages of the disease.








Vienna/Munich, March 3, 2021

Press release F4 Pharma GmbH / SIRS Therapeutics

SIRS Therapeutics and F4 Pharma announce collaboration with US company Partner Therapeutics PTx to explore potential uses of FX06 in Biodefense applications
  

 
Munich-based SIRS Therapeutics GmbH and Vienna-based F4 Pharma GmbH today announced the signature of a licensing and collaboration agreement with Massachusetts-based company Partner Therapeutics PTx. While F4 Pharma and SIRS are jointly developing FX06 in diseases associated with capillary leak – focusing on the treatment of severe COVID-19 for the time being, the potential of FX06 is going far beyond this use. Within the collaboration, the partners will explore the potential of US Government contracts and grant funding especially concentrating on chemical, biological, radiological, and nuclear countermeasure indications.

 
“We are excited to work with Partner Therapeutics, given their impressive track record in late stage development in the area of medical countermeasures for bio-threats and their industry experienced development team. In collaboration with Partners Therapeutics we are focused on exploring FX06 in areas of high interest and medical need,” said Anne Burger, CEO of SIRS Therapeutics.

 
Thomas Steiner, CEO and co-founder of F4 Pharma “the cooperation with PTx is another successful milestone in our efforts to serve critical ill patients in various serious indications. We are looking forward to addressing unmet medical needs and to starting our joint activity at the earliest.”

 
Petra Wülfroth, CSO and co-founder of F4 Pharma “The current SARS-CoV-2 pandemic has highlighted the public vulnerability caused by viruses, however, other biological or chemical threat agents can also evolve into a major public concern. FX06 has a broad applicability in diseases and pathological conditions caused by systemic inflammation and increased permeability of the blood vessels.”  She added, “We believe its mechanism of action makes it a promising tool to protect people.”

 
“We look forward to the opportunity to work with our partners at SIRS and F4 Pharma to advance the development of FX06 as a potentially important treatment for COVID-19 as well as future pandemic threats and unmet needs for medical countermeasures,” said John McManus, Chief Business Officer at Partner Therapeutics. “We believe that FX06’s activity in both animal and human models could make it a powerful potential tool for both known and unknown threats.”

 
ABOUT SIRS THERAPEUTICS
SIRS Therapeutics GmbH is a development stage biopharmaceutical company that develops FX06, a fibrin-derived peptide for the treatment of diseases related to capillary leakage e.g., ARDS in patients with underlying COVID-19 infection. The company was founded with initial investments from Wellington Partners in 2020 and is located in Germany.

 
ABOUT F4 PHARMA
F4 Pharma is a privately owned Austrian biotechnology company focusing on the development of the platform molecule FX06 in several indications with high unmet medical need. It is the intention of F4 Pharma to provide a safe and efficacious therapy to patients and physicians in critical disease situations in intensive care.

 
ABOUT PARTNER THERAPEUTICS
PTx is an integrated biotechnology company focused on the development and commercialization of late-stage therapeutics that improve health outcomes in the treatment of cancer and other serious diseases. The company believes in delivering products and supporting medical teams with the purpose of achieving superior outcomes for patients and their families.  

 
ABOUT FX06
The endothelium, i.e. the inner layer of the blood vessels, plays an important role in the homeostasis between the blood within the vessel and the surrounding tissue. In many pathological disease situations, this well-balanced equilibrium is disturbed causing an increased permeability of the blood vessel and allowing inflammatory cells to invade into the surrounding tissue. The synthetic peptide FX06 binds to the contact points between the cells, normalizes increased permeability and reduces the systemic inflammation of the endothelium.
 

Contact to F4-Pharma:

Business:
Mag.Thomas Steiner
F4 Pharma GmbH
Tel +43 6641107694

Science:
Dr. Petra Wülfroth  
F4 Pharma GmbH
Mobile +41 79 788 1800

This press release as pdf >>


Vienna, November 19, 2020

Press release F4 Pharma GmbH

COVID-19: Treatment for the most severely affected patients - after promising results in "named patient use" - clinical trial with FX06 starts in France

F4 Pharma, a clinical-stage biopharmaceutical company developing FX06, an anti-inflammatory therapeutic that has shown to improve vascular integrity, announces today the inclusion of the first patient with severe COVID-19 in a study named “FX-COVID”. The randomized, double-blind, placebo-controlled FX-COVID trial which is conducted by AP-HP (Assistance Publique – Hopitaux de Paris) in France, is set up to confirm the efficacy and safety of FX06 in hospitalized patients receiving mechanical ventilation. The goal is to show that FX06 infusion - on top of optimal medical treatment - is reducing the extracellular lung water index and is leading to improved respiratory parameters. By reducing pulmonary vascular hyperpermeability, FX06 is supposed to lead to improved lung function and reduced time of mechanical ventilation. The study will include four intensive care units and is sponsored by AP-HP, the University hospital trust operating in Paris and its surroundings, being the largest hospital system in Europe.
  
FX06, a substance discovered and developed in the Medical University of Vienna, has a dual mode of action: it is reducing the capillary leak and has anti-inflammatory efficacy. Six severely affected patients treated under named patient use exhibited improved lung function and reduced inflammatory markers. These promising results shall now be confirmed in clinical trials.

Dr. Nicolas Bréchot, Principal investigator of the FX-COVID study commented: "There is a high medical need for treatment options for the most severe cases of COVID-19 and hopefully we will be able to show a benefit for these patients in this controlled study."

Mag. Thomas Steiner, CEO and co-founder of F4 Pharma commented: "All the evidence concerning the excellent safety profile of FX06, its mode of action, its vasoprotective effect are convincing. We believe that FX06 has the potential to be an effective and important therapy for severely affected COVID-19 patients. We will apply for emergency use and conditional marketing authorization as soon as the data from the clinical trials are available."

Dr. Petra Wülfroth, CSO and co-founder of F4 Pharma commented: "FX06 has an innovative mode of action targeting the host response without affecting the innate immune system.  There is emerging evidence that the virus – in addition to affecting the lung causes damage also in other organs. This is due to a general inflammation of the endothelium, the inner layer of the small blood vessels. Our drug FX06 is working on several levels: FX06 is able to improve lung function and to ameliorate the generalized inflammatory process, thus reducing the often fatal consequences of the disease."

Anne Burger, CEO of SIRS GmbH, partner of F4-Pharma in the work on FX06 commented: "Although vaccines are occurring as a silver lining at the horizon, SARS-CoV-2 will be a part of our life for the time to come. There will be still a high medical need for an effective medication for the severe cases of COVID-19. FX06 has shown first promising results in "named patient use" and we are confident to confirm these results in clinical trials. And beyond COVID-19 there is a high potential for FX06 for further indications with a high medical need.
 

Contact to F4-Pharma:

Business:
Mag.Thomas Steiner
F4 Pharma GmbH
Tel +43 6641107694

Science:
Dr. Petra Wülfroth  
F4 Pharma GmbH
Mobile +41 79 788 1800



Vienna , October 12, 2020

Press release F4 Pharma / MCHE

F4 Pharma Announces Formation of Scientific Advisory Board

World leading clinicians and scientists support further clinical development of FX06 in diseases caused by endothelial dysfunction

After encouraging results obtained under named patient use in severe cases of COVID-19, F4 Pharma is now preparing clinical trials in several European centers with its substance FX06. There is emerging evidence that severe COVID-19 affects all organs through a systemic inflammation of the inner layer of the small blood vessels leading to increased permeability of the capillaries, which can finally result in multi-organ failure and death. The dysfunctional endothelium is the link between the pathological pathways of inflammation and coagulation observed in patients with severe COVID-19 and explains the clinical manifestations like thrombosis and disturbed microcirculation. FX06 is able to interrupt this vicious circle by interfering with the inflammatory process, thereby reducing the capillary leak and improving patient outcome.

But severe COVID-19 is not the only disease associated with capillary leak and inflammation. The same pathomechanism can be observed in multiple life-threatening diseases and is regarded as a major complication in intensive care. Therefore, a positive outcome in severely affected COVID-19 patients will serve as the starting point for the clinical development of FX06 in other diseases with a high unmet medical need.

In order to help F4 Pharma to advance FX06 and to provide strategic guidance, F4 Pharma has appointed a scientific advisory board consisting of world leading clinicians and scientists.

The scientific advisory board is led by Prof. Kai Zacharowski.

Prof. Dr. Kai Zacharowski is Director of the Department of Anaesthesiology, Intensive Care Medicine & Pain Therapy at the University Hospital Frankfurt, and is currently president of the European Society of Anaesthesiology. His main research focus is on the complex interaction between immune system and coagulation, sepsis and Patient Blood Management. He has developed an evidence-based blood management system which allows a more stringent use of blood transfusions which has an inherent risk of patients to develop severe complications (e.g. myocardial infarction, kidney failure, lung failure, pneumonia).

Dr. Nicolas Bréchot, MD, PhD is Doctor of Intensive Care Medicine at the University of Paris, Pierre et Marie Curie, and is a senior intensivist in the ICU department at the Institut de Cardiologie, Hôpital Pitié-Salpêtrière, Paris. His main research focus is on the care of critically ill cardiac patient (cardiogenic shock, acute myocardial infarction, complicated heart surgery and heart transplantation), rescue therapies for severe acute respiratory distress syndrome and inflammatory disorders.

Prof Dr. Seiji Kojima is Professor emeritus and prior Chairman of Department of Pediatrics and Director of the Pediatric Cancer Center at the Nagoya University Graduate School of Medicine. He is a pioneer of therapy for childhood aplastic anemia (AA) in Japan. He has been Chairperson of the Japan Childhood AA Study Group since 1992 and Chairperson of the AA Working Party of the Asia Pacific Bone Marrow Transplantation Group since 2009.

Prof. Dr. Patrick Meybohm is Director of the Department of Anaesthesiology, University Hospital Wuerzburg, Germany. Before, he was Deputy Director of the Department of Anaesthesiology, Intensive Care Medicine & Pain Therapy at the University Hospital Frankfurt. His research focus is on Patient Blood Management (preoperative anaemia, perioperative haemotherapy) and he has headed 10 studies as principal investigator and more than 40 studies as deputy investigator in clinical trials in Anaesthesiology and Intensive Care medicine.

Prof. Dr. Peter Petzelbauer is Head of Skin & Endothelium Research Division (SERD), Medical University Vienna, Austria. His research focus is on vascular barrier function in inflammation and cancer and he was the first person describing the function of peptide Bß15-42 now dubbed FX06.

Professor Dr. Roman Ullrich leads an intensive care unit in the Department of Anaesthesiology and an intensive care of the University Hospital (AKH) in Vienna, Austria, and is responsible for the management of the critical care units of the department.
 
Mag. Thomas Steiner, CEO and co-founder of the Austrian based F4-Pharma commented: “While the world hopes for an effective vaccine in the next months to come, COVID-19 is still growing at high pace. Further short-term development of effective therapeutics to treat severely ill patient is essential for mastering the impact of this challenging pandemic. FX06 is very well tolerated and available on short notice. All available data of FX06 outline the potential of this medication to be an effective treatment for those patients with severe disease course. Being able to put together such an outstanding, international scientific advisory board is a great distinction for us.”

Dr. Petra Wülfroth, CSO and co-founder of F4 Pharma commented: “There is emerging evidence that the virus does not only affect the lung, but also causes damage in other organs. This is due to a general inflammation of the endothelium, the inner layer of the small blood vessels. Our drug FX06 ameliorates this inflammatory process, thus reducing the often fatal consequences of the disease. F4 Pharma’s outstanding advisory board supports our endeavor to help these patients.”

Dr. Karl Nägler, Managing Partner at Munich-based venture capital firm Wellington Partners, commented: “We have provided seed financing for the further development of FX06 since we are deeply impressed by the potential benefit of FX06 in critical care in different indications. We are honored that F4-Pharma could assemble such outstanding experts for its scientific advisory board. This is invaluable for the sake of critically ill patients suffering from capillary leak and an appreciation of our investment.”

Contact to F4-Pharma:

Business:
Mag.Thomas Steiner
F4 Pharma GmbH
Tel +43 6641107694

Science:
Dr. Petra Wülfroth  
F4 Pharma GmbH
Mobile +41 79 788 1800




Vienna, June 24, 2020

Press Release MCHE / F4 Pharma and SIRS therapeutics

F4 Pharma’s FX06 shows promising results in critically ill COVID-19 patients
 
MChE / F4 Pharma and SIRS therapeutics announce promising results from treatment of six severely ill COVID-19 patients with FX06 under “named patient use”. By time of start of FX06 administration, all patients were treated in the ICU with mechanical ventilation, and five - in addition - received extracorporeal membrane oxygenation (ECMO). Within a few days following the FX06 treatment, all patients showed an improvement of lung function parameters and a significant reduction of inflammation markers. The effect may be attributed to the drug’s potent anti-inflammatory properties and its ability to reduce capillary leak and edema formation.

Dr. Petra Wülfroth, CSO and cofounder of the Austrian Vienna-based Biotech F4 Pharma stated: “Given the severity of the disease and the poor prognosis of these patients, the favorable clinical response observed in all patients, resulting in the survival of four out of six patients, exceeded our expectations. We believe that the use of FX06 in severe cases of COVID-19 associated with ARDS and endotheliitis could be an effective therapy to improve the disease course of the patients needing mechanical ventilation and ECMO. These first results in named patient use settings are to be confirmed in upcoming clinical trials.”

Mag. Thomas Steiner, CEO and co-founder of F4 Pharma, stated: “Anti-viral substances have shown interesting results in early stages of COVID-19, however their merits in the treatment of severely ill patients have still not been proven. Immunosuppressive strategies such as IL-6 antagonists or steroids have shown some results lately. The results obtained in named patient use applications with FX06 are indicating that our substance could become an important component in the therapy of severely ill COVID-19 patients, complementing anti-viral strategies or specific immunosuppressive medication.  Results of named patient use treatments call for confirmation in controlled clinical trials. We have filed for authorization with ethical committees last week and look forward to the clinical studies being prepared at renowned European clinical centers.”  

Dr. Rainer Strohmenger, Managing Partner at Munich-based venture capital firm Wellington Partners, commented: “We have decided to financially support the clinical development of FX06, because we are convinced that this drug candidate can be of benefit for patients in a variety of severe clinical conditions associated with system inflammation and vascular leakage. In our opinion, the promising results from first compassionate use in COVID-19 patients are confirming this hypothesis.”  

FX06 is a naturally occurring peptide, Bβ15-42, derived from the E1 fragment of fibrin. The mechanism of action of FX06 is an important new discovery in understanding acute inflammation and edema formation. Based on animal models of vascular leakage and systemic inflammation, FX06 has considerable therapeutic potential for all diseases and pathological conditions associated with increased vascular permeability and inflammation of the endothelium i.e. the inner layer of blood vessels.

Contact:
     
MChE /F4-Pharma

Business:
Mag.Thomas Steiner
F4 Pharma GmbH
Tel +43 6641107694

Science:
Dr. Petra Wülfroth  
F4 Pharma GmbH    
Mobile +41 79 788 1800

Wellington Partners

Dr. Rainer Strohmenger, Managing Partner  
Via Ulrike Hartl
+49 (0) 89 219941-20

 


 
Vienna, April 15, 2020

Press Release MCHE / F4 Pharma
Financing / Covid-19

FX06 treatment for severely ill patients

MChE / F4-Pharma, an Austrian clinical stage biopharmaceutical company, has received financing from Wellington Partners, a leading European venture capital firm investing in early and growth stage life  science companies, via its newly-founded portfolio company SIRS Therapeutics, Munich Germany.

FX06 is a platform molecule with a novel mode of action. FX06  binds to the so-called adherence junctions between the endothelial cells which are forming the inner layer of blood vessels. In doing so, the drug preserves the integrity of the endothelium and prevents the leakage of fluid from the blood vessel into the surrounding tissue. In addition FX06 also has anti-inflammatory properties. The drug was already investigated in another - mechanistically related – indication and has demonstrated convincing efficacy in a clinical study with 236 patients. FX06 was very well tolerated and exhibited a benign safety profile.

In early 2020, Sars-CoV-2 (COVID-19) represents, after MERS and SARS, the third epidemic caused by coronaviruses in the 21st century. To date, SARS-CoV2 has evolved to a global pandemic with +2,000,000 confirmed cases and +120,000 deaths in + 180 countries, numbers in most countries still growing exponentially. In general, most COVID-19 patients experience mild to moderate symptoms including fever, cough, dyspnoea, taste disturbances or muscle pain. However, thoracic x-rays of some patients present bilateral infiltrations known from interstitial pneumonia. Critically ill patients, which constitute 2-9% of all infected, progress from first symptoms and diagnosis to hypoxia and pneumonia and can reach life threatening ARDS, for which acute treatment options are scarce.

FX06 has the potential to become an effective novel therapeutic for treatment of severely ill Covid-19 patients: SIRS and F4-Pharma - joint owners of all rights to FX06 - have initiated final steps of GMP production for the drug material and are planning and preparing for a multi-center clinical study in Vienna, Frankfurt and Würzburg. Further clinical centers might be included in the trials.

Thomas Steiner, CEO of MChE/F4 Pharma, and Co-founder Dr. Petra Wülfroth explained: "Based on our knowledge and expertise we are convinced that FX06 can help severely ill Covid-19 patients. We are extremely pleased having gained the support of Wellington Partners for the development of FX06 in severely infected COVID-19 patients. Our mission is to make FX06 available for clinical testing in this indication of highest unmet medical need within the next couple of weeks. Our hope is that patients may respond to FX06 treatment in a similar favorable way as it was shown under compassionate use during the 2014 outbreak of Ebola in a case study published in Lancet."

Dr. Rainer Strohmenger, Managing Partner of Wellington Partners, commented: "We believe that FX06 could provide immediate value in the treatment of critically ill COVID-19 patients with impaired lung function, sepsis  and ARDS. The investment into SIRS Therapeutics has been made to accelerate the clinical development of this compound, which has already proven to be safe with strong hints for clinical efficacy in related pathologies on the basis of a well understood mechanism of action."

Contact details:

MChE / F4-Pharma
Business:
Mag. Thomas Steiner,
thomas.steiner@f4-pharma.com, Tel.: +43 6641107694

Science:
Dr. Petra Wülfroth
F4 Pharma GmbH i.G.
petra.wuelfroth@f4-pharma.com, Mobile: +41 79 788 1800

Wellington Partners
Dr. Rainer Strohmenger, Managing Partner via Ulrike Hartl hartl@wellington-partners.com, Tel.: +49 (0) 89 219941-20




Wien, 15. April 2020
Presse Aussendung MCHE / F4 Pharma
Finanzierung / Covid-19

FX06 Behandlung schwer erkrankter Patienten

Bereits im Heilversuch bei einem Ebola Patienten eingesetzt, hat die im Wiener AKH entdeckte Substanz FX06 das Potenzial, schwer erkrankten Covid-19 Patienten zu helfen. Eine Finanzierung durch den Venture Capital Fonds Wellington Partners ermöglicht nun den Eintritt in klinische Studien.

Von Professor Peter Petzelbauer am Wiener AKH entdeckt, hat die Substanz FX06 in zahlreichen wissenschaftlichen Studien ihre Wirksamkeit an Tiermodellen nachgewiesen. In einer Studie mit 236 Patienten mit Herzinfarkt wurde die gute Verträglichkeit von FX06 gezeigt und die klinische Wirksamkeit der Substanz zur Verhinderung von entzündlichen Gewebsschädigungen (Reperfusionssyndrom) nachgewiesen.

FX06 ist weder der ersehnte Covid-19 Impfstoff noch eine anti-virale Substanz, sondern soll zur Behandlung schwer erkrankter Covid-19 Patienten mit generalisierten Entzündungsreaktionen eingesetzt werden. ARDS, Sepsis und septischer Schock gehören zu den lebensbedrohlichen Komplikationen, deren Auswirkungen es zu bekämpfen gilt. Genau das tut FX06, indem es den sogenannten "Capillary Leak" bekämpft. Damit bezeichnet man einen Zustand, bei dem die kleinsten Blutgefäße, die Kapillaren, aufgrund der heftigen Abwehrreaktion des Immunsystems gegen den Virus "löcherig" werden, und zu viel Flüssigkeit und Entzündungszellen aus dem Blut ins Gewebe gelangen. In der Lunge kommt es dadurch zur Ödembildung und zur Behinderung des Sauerstoffaustausches.

Während der vorangegangenen Ebola-Krise in West-Afrika wurde ein an Ebola erkrankter ugandischer Kinderarzt – er hatte sich bei einer Geburtshilfe infiziert – an die Universitätsklinik Frankfurt evakuiert. Er musste bald künstlich beatmet werden und war in einem lebensbedrohlichen Zustand. Ein Frankfurter Team um Professor Dr. Dr. Kai Zacharowski setzte FX06 zu seiner Behandlung ein und konnte die Lungenfunktion des Patienten verbessern. Der Patient wurde gerettet und hat sich wieder vollständig erholt.

Aufgrund der Ergebnisse dieses Heilversuches und der zahlreichen positiven klinischen und präklinischen Untersuchungen geht F4-Pharma, ein österreichisches Start-up Unternehmen, davon aus, dass FX06 schwer erkrankten Covid-19 Patienten helfen und viele Leben retten könnte. Bereits vorhandene FX06-Substanz soll daher für die klinische Erprobung an Zentren in Europa zur Verfügung gestellt werden.

Dank einer Finanzierung durch den Münchner Venture Capital Fonds Wellington Partners können die Vorbereitungen für klinische Studien in Wien, Paris, Frankfurt und Würzburg getroffen werden. Alle betroffenen Kliniken behandeln bereits schwer erkrankte Covid-19 Patienten und arbeiten gemeinsam mit der F4-Pharma an der Entwicklung des klinischen Protokolls. Die weitere klinische Entwicklung von FX06 wird jedoch die finanziellen Möglichkeiten von F4-Pharma weit übersteigen.

Ohne den erklärten Willen der österreichischen Bundesregierung, die Entwicklung von Therapieverfahren und die Planung und Durchführung von klinischen Studien im Rahmen des FFG Emergency Calls zur Erforschung von Covid-19 zu fördern, wäre es schwierig, das Potential des österreichischen Standortes für die Bekämpfung der Covid-19 Krise auszuschöpfen.

Mag. Thomas Steiner, Geschäftsführer der MChE / F4-Pharma meint dazu: "Covid-19 ist nicht die einzige Indikation, bei der FX06 einen wichtigen therapeutischen Beitrag leisten kann. Wir haben  großartige Forscher und Kliniker in Österreich. Die staatliche Unterstützung unserer klinischen Studien ist ein wichtiger und richtiger Schritt."

Dr. Rainer Strohmenger, Managing Partner bei Wellington Partners, ergänzt: "Wir glauben fest an das Potenzial von FX06 in der intensivmedizinischen Behandlung von Covid-19 Patienten. Die bisherige Datenlage und der gut erforschte Wirkmechanismus der Substanz lassen darauf hoffen, dass FX06 einen wichtigen Beitrag zur Rettung vieler Patienten mit Lungenversagen leisten kann. Gleichzeitig hat sich FX06 bereits als sehr gut verträglicher Wirkstoff erwiesen."

MChE /F4-Pharma

Zum Unternehmen:
Mag. Thomas Steiner,
thomas.steiner@f4-pharma.com, Tel +43 6641107694

Zur Wissenschaft:
Dr. Petra Wülfroth
F4 Pharma GmbH i.G.,
petra.wuelfroth@f4-pharma.com, Mobile +41 79 788 1800

Wellington Partners
Dr. Rainer Strohmenger, Managing Partner via Ulrike Hartl, hartl@wellington-partners.com Tel +49 (0) 89 219941-20




December 19, 2014:

Paper about FX06 in The Lancet: Doctor who survived Ebola received experimental drug treatment [read]

Bloomberg report: Ebola Doctor’s Recovery Shows Promise of Resurrected Lung Drug [read]



November 10, 2014 – Press release:

F4 Pharma’s developmental drug FX06 successful in treating vascular leak in Ebola

First highly encouraging results in treating an Ebola infected patient in Frankfurt with FX06

The University Hospital in Frankfurt reported the successful treatment of an Ebola patient medically evacuated from Sierra Leon. The compound FX06, developed in Austria, was used by experts of the University Hospital in Frankfurt under compassionate use after approval by the ethic committee. FX06 could substantially contribute to the recovery of the patient. The substance had been developed by a scientist at the Vienna General Hospital (AKH) and has the potential to decisively influence the outcome of an Ebola infection.

"Originally we wanted to focus on another indication and were in the course of raising funds when we realized that all our preclinical and clinical data of FX06 are addressing principally one of the most dramatic disease patterns of Ebola, the so-called ‘vascular leak’. FX06 is sealing the walls of the blood vessels which become leaky during the disease course with the consequence of severe and irreparable damage of vital organs like kidney, liver and lung." This can be life saving" declares Mr. Thomas Steiner. The Viennese entrepreneur is CEO of the company MChE F4-Pharma.
"We had already been in contact with the WHO and other international organizations when we received the request from Frankfurt. Fortunately the manufacturer of our substance, Bachem, was able to deliver FX06 immediately and in an un-bureaucratic procedure to Frankfurt."

"We actually created the prerequisites for further compassionate use in Europe and our drug is stored centrally at the  University of Frankfurt. Now the challenge is to overcome any arising further regulatory documentations before we can start a clinical trial in West Africa” states the biotechnical expert Dr. Petra Wülfroth of F4-Pharma.

The cooperation with the team at the University Hospital in Frankfurt, headed by Prof. Dr. Kai Zacharowski, is a cardinal point to facilitate the use of FX06 in specialized centers in Europe and also in West Africa at the earliest convenience. The scientific research performed in intensive care units in European and US are prerequisites to understand the course of this striking epidemic.

"As a matter of fact MChE F4-Pharma is in urgent need of support and is looking for further funds. We hope to be able to count on investors of the public and private sector in order to have FX06 ready as soon as possible against Ebola world-wide" concludes Mr. Steiner. The manufacturer of FX06, Bachem, already donated material in the value of several 100.000 Euro.




November 6, 2014:

Peptide FX06 has been applied in the medication of an Ebola patient in Frankfurt.
Below you find some press reports on this topic:

  • t-online - Nov 5, 2014: Uniklinik Frankfurt setzt neuen Wirkstoff gegen Ebola ein [read]
  • Reuters - Nov 5, 2014: German doctors use experimental heart drug in treating Ebola patient [read]
  • vienna online - Nov 5, 2014: Die Entwicklung des möglichen Ebola-Medikaments FX06 [read]
  • Wiener Zeitung- Nov 5, 2014: Wiener Arznei half in Frankfurt bei Ebola [read]
  • vienna online - Nov 5, 2014: Ebola – Medikament kommt aus Wien: Erster Patient mit FX06 behandelt [read]
  • Kronen Zeitung - Nov 5, 2014: Wiener Medikament neue Hoffnung gegen Ebola [read]

   

F4 Pharma GmbH - © 2021
Page modified: November 23, 2021
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